PONV is an unwelcome problem in the peri-operative period.
Effective drug treatment requires a planned management protocol that includes intravenous anti-emetic administration at appropriate time intervals (ie, if a specific agent hasn't worked by the time it should have, give something else!). Drugs included in a PONV protocol should span the range of pathways involved. Medical review is needed for any patient with refractory PONV to exclude a surgical or medical cause.
When reviewing abstracts, note the difference between prophylaxis and treatment protocols, and also between nausea and vomiting. Hospitals should have a prophylaxis protocol that identifies at-risk groups and the agent/s they should be offered, and independently a treatment protocol for nurses to use in the peri-operative period for anyone afflicted with PONV.
Annalyn Kuok provides this point-form summary of PONV and its management.
Paul White discussess 5-HT3 antagonists in the ambulatory setting.
If you're registered, this MedScape article is good.
Questions about the Virtual Anaesthesia Textbook project itself should be e-mailed to Chris Thompson.